Intramuscular Delivery Of Gene Therapy for Targeting The Nervous System

There is such a thing called virus mediated therapy, that has the potential to deliver a great amount of gene material into specific cell types to promote survival and counteract disease. If we are to insert the gene therapy virus into the skeletal muscles as well as the brain stem and the brain itself, it could be a miracle worker. These viruses must undergo a series of processes before being transmitted. They must have host cell interaction as well as internalization, intracellular sorting, long range retrograde axonal transport, endosomal liberation, and nuclear transportation to the right areas of the axons, neurons and the brain stem. Gene therapy is a great promise for anything that is acting the nervous system. The FDA has now approved in the US RPE65- associated retinal dystrophy. As well as SMN1 – linked spinal muscular atrophy; as well as non neural conditions. Crucial to this is at some of these viral vectors have an important role in tackling the blood that gets built up in our brains as well as the spinal cord. When intravenously injecting these viruses into the cerebrospinal fluid, it can also admit for the targeting of the peripheral (PNS) and central nervous system (CNS). Virus intravenous through the muscles is also a new way of doing things. This is the beginnings to healing Alzheimers, Parkinson’s, and any neurodegenerative diseases that scientists now understand how to tackle!!


Laura Zukerman

The Goddess Bibles

A Memoir By Laura Zukerman